Synthesis and Characterization of Ursolic Acid Loaded Poly (Lactic-Co-Glycolic Acid) Nanoparticles and Caffiene Loaded Poly (Lactic-Co-Glycolic Acid) Nanoparticles in Colorectal Cancer Cell Line

Colorectal cancer is the fourth most frequently diagnosed cancer and the second leading cause of cancer death. About 96,830 new cases of colon cancer and approximately 40,000 cases of rectal cancer will occur and 50,310 people will die of colon and rectal cancer combined[1]. The long term survival rate of colon cancer patients treated by conventional modalities such as surgery, radiation, and chemotherapy remains far from satisfactory[2]. Colon cancer cells are only the modestly responsive or even nonresponsive to the cytotoxic effects of chemotherapeutic agents[3]. The term “chemo sensitization” was originally introduced as a strategy to counter the development of resistance in tumor cells to anticancer chemotherapeutic agents. Simply put, chemo sensitization in cancer therapy involves use of a chemical 1PG & Research Department of Zoology, Muslim Arts College, Thiruvithancode, Tamilnadu, India 2PG & Research Department of Zoology, Government Nandanam Arts College Chennai, Tamilnadu, India 3Department of Biochemistry, Theivanai Ammal College for Women Villupuram, Tamilnadu, India